Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age.

The study found that prenatal e-cigarette exposure in mice led to decreased expression of tight junction proteins, astrocyte marker GFaP, and aqP4 water channel protein in offspring's brains. These changes were associated with impaired motor, learning, and memory function in adolescent and adult offspring. The study suggests that maternal e-cigarette use during pregnancy could pose potential risks to the neurovascular health of offspring.

archie SR, Sifat aE, Zhang Y, et al. Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age. Fluids and barriers of the CNS. 2023;20(1):17. doi:10.1186/s12987-023-00416-5