Summary
This study investigates the cytotoxic effects of individual and binary mixtures of a representative terpene (+-R-limonene) and diluent (triethyl citrate) on human lung cell models. The results show that limonene was more cytotoxic than triethyl citrate and that the 97:3% v/v mixture resulted in an antagonistic chemical interaction, while the 80:20% v/v mixture resulted in a similar result. The study highlights the need for further testing of different ratios of binary mixtures to inform safety assessments.
Citation
Baldovinos Y, archer a, Salamanca J, Strongin RM, Sayes CM. Chemical Interactions and Cytotoxicity of Terpene and Diluent Vaping Ingredients. Chemical research in toxicology. 2023;36(4):589-597. doi:10.1021/acs.chemrestox.2c00218
