Examining the association of habitual e-cigarette use with inflammation and endothelial dysfunction in young adults: The VaPORS-Endothelial function study.

Introduction:
This text provides an analysis of a study examining the association between habitual e-cigarette use and inflammation and endothelial dysfunction in young adults. The study aims to assess the potential cardiovascular risks associated with e-cigarette use.

Key Points:

* The study is a cross-sectional analysis of 46 participants, with 23 exclusive e-cigarette users and 23 non-users.
* E-cigarette users had used e-cigarettes for at least 6 consecutive months, while non-users had used e-cigarettes less than 5 times and had negative urine cotinine tests.
* Endothelial dysfunction was measured using flow-mediated dilation (FMD) and reactive hyperemia index (RhI), and inflammation was measured using high-sensitivity C-reactive protein, interleukin-6, fibrinogen, p-selectin, and myeloperoxidase.
* after adjusting for confounding factors, the study found no significant difference in FMD or RhI between e-cigarette users and non-users.
* Similarly, there was no significant difference in the levels of inflammatory markers between the two groups.
* The study suggests that e-cigarette use may not be significantly associated with endothelial dysfunction and systemic inflammation in relatively young and healthy individuals.
* The authors note that longer-term studies with larger sample sizes are needed to validate these findings.

Main Message:
The study provides important insights into the potential cardiovascular risks associated with e-cigarette use. While the study has some limitations, such as a small sample size and cross-sectional design, it suggests that habitual e-cigarette use may not be significantly associated with endothelial dysfunction and systemic inflammation in young adults. however, further research is needed to confirm these findings and to better understand the long-term health effects of e-cigarette use. Overall, the study highlights the need for continued research and regulation of e-cigarettes to ensure public health and safety.

Boakye E, Uddin SMI, Osuji N, et al. Examining the association of habitual e-cigarette use with inflammation and endothelial dysfunction in young adults: The VaPORS-Endothelial function study. Tobacco induced diseases. 2023;21:75. doi:10.18332/tid/162327