Electronic cigarette exposure reduces exercise performance and changes the biochemical profile of female mice.

Introduction:
This text summarizes a scientific study examining the effects of electronic cigarette (EC) exposure on exercise performance and health-related profiles in a mouse model. The study investigates the subchronic toxic effects of different doses of EC for exercise performance and basic health parameters.

Key Points:

* The study used female ICR mice and divided them into five groups, each exposed to a different EC dose or control condition for 14 days.
* Exposure to EC led to a dose-dependent decrease in grip strength and swimming time in the mice.
* EC-treated groups showed a dose-dependent decrease in liver and muscle glycogen storage.
* No negative effects or gross abnormalities were detected in biochemical indices or major organs.
* EC exposure did not affect body weight, food, or water intake but did increase heart weight and relative heart weight in a dose-dependent manner.
* Uric acid levels were significantly higher in the EC-exposed groups, suggesting an increased risk of heart disease and obesity.
* No histopathological abnormalities were found in the tissues or organs of the mice exposed to EC.

Main Message:
The study suggests that EC exposure can negatively impact exercise performance and increase the risk of heart disease in a mouse model. Specifically, EC exposure led to decreased grip strength, swimming time, and liver and muscle glycogen storage. additionally, EC exposure increased heart weight, relative heart weight, and uric acid levels. These findings highlight the potential health risks associated with EC use and warrant further investigation in human populations.

Chen YM, huang CC, Sung hC, Lee MC, hsiao CY. Electronic cigarette exposure reduces exercise performance and changes the biochemical profile of female mice. Bioscience, biotechnology, and biochemistry. 2019;83(12):2318-2326. doi:10.1080/09168451.2019.1651627