E-cigarettes: Impact of E-Liquid Components and Device Characteristics on Nicotine Exposure

The sources provided discuss the following findings related to alcohol and nicotine use, specifically in the context of e-cigarettes:

1. Co-occurring alcohol and tobacco use:
* a study analyzing data from the National Epidemiologic Survey on alcohol and Related Conditions found a high prevalence of co-occurring alcohol and tobacco use and disorders (Falk et al., 2006).
2. Nicotine levels in e-cigarettes:
* Research has shown that e-liquid nicotine levels may not always match labeling, which is an important consideration for researchers studying e-cigarettes (hershberger et al., 2016).
* Inaccurate e-liquid nicotine labeling could have clinical implications, as it may influence nicotine delivery and metabolism (Prendergast et al., 2016).
3. alcohol in e-cigarettes:
* alcohol in e-cigarettes may influence nicotine effects and metabolism, particularly if delivered chronically in sufficient levels (Prendergast et al., 2016).
4. Nicotyrine and e-cigarettes:
* a hypothesis suggests that nicotyrine, when present, may optimize nicotine delivery and withdrawal-suppressing effects of e-cigarettes (Prendergast et al., 2016).
5. Puff topography and e-cigarette use:
* E-cigarette users may adjust puff topography to compensate for lower efficiency devices and achieve desired nicotine levels (Prendergast et al., 2016).
* No significant difference in puff topography was found between e-cigarette only users and dual users of e-cigarettes and combustible cigarettes (Prendergast et al., 2016).

These findings highlight the complex relationship between alcohol and nicotine use, as well as the importance of accurate labeling and understanding puff topography in e-cigarette research.

DeVito, Elise E., and Suchitra Krishnan-Sarin. “E-Cigarettes: Impact of E-Liquid Components and Device Characteristics on Nicotine Exposure.” Current Neuropharmacology 16, no. 4 (May 1, 2018): 438–59. https://doi.org/10.2174/1570159X15666171016164430.