Biomarkers of Exposure and Biomarkers of Potential harm in adult Smokers Who Switch to e-Vapor Products Relative to Cigarette Smoking in a 24-week, Randomized, Clinical Trial.

Introduction:
This text presents the findings of a study examining the effects of switching from cigarettes to electronic vapor products (EVPs) on biomarkers of exposure (BoEs) and biomarkers of potential harm (BoPhs) in adult smokers. The study followed a group of adult smokers who were randomly assigned to continue smoking or switch to one of two cartridge-based EVPs for 24 weeks.

Key Points:

* The study found that switching to EVPs resulted in significant reductions in BoEs, including nicotine, NNaL, COhb, and several other harmful and potentially harmful constituents.
* The reductions in BoEs were accompanied by favorable changes in BoPhs, including white blood cell count, hDL-C, 8-epi-PG, and several measures of pulmonary function.
* The changes in BoEs and BoPhs approached those observed in smoking cessation studies, suggesting that switching to exclusive use of EVPs may be less harmful than continuing smoking.
* The study was conducted by altria Client Services LLC and was funded by altria.

Main Message:
The main message of this text is that switching from cigarettes to EVPs can result in significant reductions in exposure to harmful and potentially harmful constituents, as well as favorable changes in biomarkers of potential harm. These findings suggest that switching to exclusive use of EVPs may be less harmful than continuing to smoke cigarettes. however, it is important to note that the study was conducted by a tobacco company and was funded by altria, which may raise concerns about potential bias. Overall, the findings of this study add to the growing body of evidence suggesting that EVPs may be a less harmful alternative to cigarettes for adult smokers who are unable or unwilling to quit.

Edmiston JS, Webb KM, Wang J, Oliveri D, Liang q, Sarkar M. Biomarkers of Exposure and Biomarkers of Potential harm in adult Smokers Who Switch to e-Vapor Products Relative to Cigarette Smoking in a 24-week, Randomized, Clinical Trial. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2022;24(7):1047-1054. doi:10.1093/ntr/ntac029