TOXICOLOGICaL REVIEW OF aCROLEIN (CaS No. 107-02-8) In Support of Summary Information on the Integrated Risk Information System (IRIS)

Based on the information provided, the following can be summarized regarding acrolein:

1. acrolein's carcinogenic potential cannot be determined with certainty based on oral exposure studies due to negative findings in two out of three studies and uncertain significance of intraperitoneal injection studies.
2. acrolein did not produce a carcinogenic response in two inhalation studies or in a skin tumor initiation-promotion study.
3. an independent pathology working group was used to evaluate the findings from each exposure group, and the study was considered a supporting study.
4. acrolein has been found to increase airway mucin transcripts in epithelial cells, both directly and indirectly via inflammatory mediators.
5. Irritants like acrolein can increase MUC5aC message levels, whereas MUC5B is constitutively expressed. When transcription is inhibited, TNF-alpha exposure increases MUC5aC message half-life compared with control level, suggesting that transcript stabilization is a major mechanism controlling increased MUC5aC message levels.

“TOXICOLOGICaL REVIEW OF aCROLEIN (CaS No. 107-02-8) In Support of Summary Information on the Integrated Risk Information System (IRIS).” US Environmental Protection agency (EPa), May 2003. EPa/635/R-03/003.