Interactive effects of protonated nicotine concentration and device power on ENDS nicotine delivery, puff topography, and subjective effects.

Introduction:
This document presents a study examining the interaction between protonated nicotine liquid concentration and device power output on plasma nicotine concentration, sensory and subjective effects, and puff topography in electronic nicotine delivery systems (ENDS). The study aims to understand the effects of these factors on the user experience and nicotine delivery, particularly in the context of regulations targeting nicotine delivery.

Key Points:

* The study used a within-subjects design with two groups: ENDS users and cigarette smokers.
* Participants used a single variable wattage ENDS device at different power settings and nicotine concentrations.
* Plasma nicotine concentration, puff topography, and subjective effects were measured.
* Increased liquid concentration and device power output led to increased plasma nicotine concentration.
* higher liquid concentration and greater device power output were associated with increased ratings of harshness, flavor, and throat hit.
* Puff topography was influenced by liquid nicotine concentration and device power, with higher concentrations and power resulting in decreased puff duration and volume.
* Group differences were observed for sensory effects and puffing behavior, with cigarette smokers rating throat hit and flavor higher and ENDS users taking longer puffs.

Main Message:
This study emphasizes the importance of considering both liquid nicotine concentration and device power output when regulating ENDS. Comprehensive regulations should include limits on puff duration and nicotine flux to effectively control nicotine delivery to the user, independent of the nicotine concentration of the liquid and the form of the nicotine in the liquid.

Eversole a, Budd S, Karaoghlanian N, Lipato T, Eissenberg T, Breland aB. Interactive effects of protonated nicotine concentration and device power on ENDS nicotine delivery, puff topography, and subjective effects. Experimental and clinical psychopharmacology. 2023;31(2):443-454. doi:10.1037/pha0000576