actual Use Behavior assessment of a Novel Puff Recording Electronic Nicotine Delivery System: Observation Study.

Introduction:
This text discusses a study on the actual use behavior assessment of a novel puff recording electronic nicotine delivery system (PR-ENDS) in real-world conditions. The study aimed to analyze and summarize the survey and PR-ENDS use data and to study the relationships and effects of different factors on these variables.

Key points:

* The study enrolled 61 UK e-cigarette users who were instructed to use PR-ENDS as their primary source of nicotine with their selected e-liquids for at least 3 weeks.
* The puff data was directly recorded by PR-ENDS and uploaded to the cloud for further analyses. The nicotine emission and nicotine consumption were estimated based on recorded puff data.
* The study found that middle-aged adults with a nicotine history represented the major user profile during the PR-ENDS trial. a wide range of device power and e-liquid nicotine concentrations was applied and their combinations during actual use were found to be rather complex.
* Various puff parameters (ie, puff duration, puff number, nicotine emission) were assessed with contributing factors from device, e-liquid, and user nicotine history in different effect sizes.
* The real-time observation revealed substantial intra- and inter-individual variabilities in PR-ENDS use behaviors. The use pattern of a quick adaptation followed by consistent product use was recognized for at least 3 weeks during actual use.

Main message:
The actual use behavior assessment of PR-ENDS provided new insights into compensatory behavior, which can inspire future studies in the field of nicotine addiction and abuse liability behavior assessment. The complex interactions of product attributes and significant intra- and inter-individual variabilities in e-cigarette use behaviors highlight the need for further research in this area. The study also demonstrates the potential of PR-ENDS as a tool for monitoring e-cigarette use behaviors in real-time, which can inform regulatory bodies on product use trends and help identify early signs of use inappropriate for the protection of public health.

Gao X, humberstone L, Liu Y. actual Use Behavior assessment of a Novel Puff Recording Electronic Nicotine Delivery System: Observation Study. JMIR formative research. 2023;7:1. doi:10.2196/43175