Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures.

Introduction:
This text discusses a study comparing the biological impact of an e-vapor device with MESH technology and cigarette smoke on human bronchial and alveolar cultures. The study used a systems toxicology approach to evaluate the exposure effects at the molecular level.

Key Points:

* The study used human organotypic bronchial epithelial culture and alveolar triculture models.
* Exposure to the e-vapor device did not cause cytotoxicity in bronchial epithelial cultures or alveolar tricultures, unlike cigarette smoke exposure.
* Ciliary beating frequency was significantly decreased in bronchial cultures exposed to cigarette smoke but not in those exposed to the e-vapor device.
* Global mRNA expression and secreted protein profiles revealed a significantly lower impact of e-vapor device exposure compared to cigarette smoke exposure.
* The study concludes that the exposure to the e-vapor device has a clearly reduced impact on bronchial and alveolar cultures, even at greater nicotine doses.

Main Message:
The study provides evidence that an e-vapor device with MESH technology has a reduced biological impact on human bronchial and alveolar cultures compared to cigarette smoke. The results suggest that e-cigarettes may pose less risk to human health than traditional cigarettes. However, further research is needed to confirm these findings and to evaluate the long-term health effects of e-cigarette use.

Giralt A, Iskandar AR, Martin F, et al. Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures. Toxicology letters. 2021;337:98-110. doi:10.1016/j.toxlet.2020.11.006