Computational transport, phase change and deposition analysis of inhaled multicomponent droplet–vapor mixtures in an idealized human upper lung model

The studies provided focus on the computational analysis of airflow, particle deposition, and evaporation in the human respiratory tract, specifically in the nasal, oral, and tracheobronchial airways. Researchers have used various computational models to study the deposition and phase changes of particles, droplets, and vapors, which can consist of different substances, such as nicotine, nanoparticles, and volatile organic compounds (VOCs). The findings help understand the mechanisms of particle transport, deposition, and phase changes, which are crucial in assessing the health risks associated with inhaled pollutants.

In summary, the research covers:

1. Analysis of airflow and nanoparticle deposition in combined nasal-oral-tracheobronchial airway models (Zhang & Kleinstreuer, 2011; Feng & Kleinstreuer, 2011).
2. Size-change and deposition of conventional and composite cigarette smoke particles during inhalation (Zhang et al., 2012a).
3. Vapor deposition during cigarette smoke inhalation in a subject-specific human airway model (Zhang et al., 2012b).
4. Deposition and phase change of inhaled semi-volatile liquid droplets in the nasal passages of rats and humans (Schroeter et al., 2016).
5. Transport and uptake of vapors, like MTBE and ethanol, in a human upper airway model (Zhang et al., 2006; Feng, 2013).
6. Comparison of micro- and nano-size particle depositions in a human upper airway model (Zhang et al., 2005).
7. The role of gas/particle partitioning in the deposition of nicotine and other tobacco smoke compounds (Pankow, 2001).

These studies contribute to understanding the behavior of inhaled particles, droplets, and vapors, which is essential for developing exposure assessment strategies and risk management policies.

Feng, Yu, Clement Kleinstreuer, Nicolas Castro, and Ali Rostami. “Computational Transport, Phase Change and Deposition Analysis of Inhaled Multicomponent Droplet–Vapor Mixtures in an Idealized Human Upper Lung Model.” Journal of Aerosol Science 96 (June 2016): 96–123. https://doi.org/10.1016/j.jaerosci.2016.03.001.