E-cigarette aerosol impairs male mouse skeletal muscle force development and prevents recovery from injury.
Nonclinical
Safety Effects In Animals
Repeat-dose
Nogueira (2022)
Effects of Chronic Nicotine Inhalation on Systemic and Pulmonary Blood Pressure and Right Ventricular Remodeling in Mice.
Nonclinical
Safety Effects In Animals
Repeat-dose
Oakes (2020)
Evaluation of the Tobacco heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke
Non-Clinical
Safety Effects In Animals
Repeat-dose Toxicity
Oviedo (2016)
Strawberry additive Increases Nicotine Vapor Sampling and Systemic Exposure But Does Not Enhance Pavlovian-Based Nicotine Reward in Mice.
Nonclinical
Safety Effects In Animals
Repeat-dose
Patten (2023)
Increased sensitivity to D9-ThC-induced rewarding effects after seven-week exposure to electronic and tobacco cigarettes in mice.
Nonclinical
Safety Effects In Animals
Non-Clinical Of Nicotine & Cotinine
Ponzoni (2019)
Exposure to e-cigarette aerosol over two months induces accumulation of neurotoxic metals and alteration of essential metals in mouse brain.
Nonclinical
Safety Effects In Animals
Repeat-dose
Re (2021)
Metabolomics-based safety evaluation of acute exposure to electronic cigarettes in mice.
Nonclinical
Safety Effects In Animals
Acute Exposure
Ren (2022)
E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an apoE-/- mouse model.
Nonclinical
Safety Effects In Animals
Repeat-dose
Reumann (2020)
Prenatal nicotine increases pulmonary α7 nicotinic receptor expression and alters fetal lung development in monkeys
Non-Clinical
Safety Effects In Animals
Non-Clinical
Of Nicotine &
Cotinine
Sekhon (1999)
a mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers.
Nonclinical
Safety Effects In Animals
Repeat-dose
Shao (2019)